SITAPRED 50/1000 is a combination tablet containing Sitagliptin and Metformin, used to control blood sugar levels in adults with type 2 diabetes mellitus. Sitagliptin, a DPP-4 inhibitor, enhances incretin hormone activity, promoting insulin release and lowering glucagon levels. Metformin, an antihyperglycemic agent, reduces liver glucose production and increases insulin sensitivity. Together, this combination provides dual-action glycemic control, aiding in the management of diabetes and reducing the risk of complications. SITAPRED 50/1000 is available in 10x15 blister packaging.HOW DOES IT WORK?Sitagliptin works by inhibiting the enzyme DPP-4, which prolongs the action of incretin hormones that stimulate insulin release in response to meals and reduce glucagon secretion. Metformin primarily decreases glucose production in the liver and enhances insulin sensitivity, improving the body’s ability to utilize glucose. This combined mechanism allows for effective blood sugar management throughout the day without significantly increasing the risk of hypoglycemia.SIDE EFFECTSWhile SITAPRED 50/1000 is generally well-tolerated, some patients may experience mild side effects, such as:
Nausea
Diarrhea
Headache
Respiratory tract infection
Hypoglycemia (rarely)
Patients should consult their healthcare provider if any side effects persist or worsen. Metformin may rarely cause lactic acidosis, a serious side effect that requires immediate medical attention.ADMINISTRATION OF DOSESSITAPRED 50/1000 is typically prescribed as one tablet taken once or twice daily with meals to reduce the risk of gastrointestinal discomfort. Dosage adjustments may be necessary based on blood sugar control and individual tolerance. It is crucial for patients to follow their healthcare provider’s dosing instructions carefully and not exceed the prescribed dose.BENEFITS
Effectively manages blood sugar levels in type 2 diabetes, helping reduce the risk of complications associated with high blood sugar(Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 13th Edition)
Combines two complementary mechanisms, enhancing insulin release and sensitivity while lowering hepatic glucose production(Katzung & Trevor's Basic and Clinical Pharmacology, 14th Edition)
INDICATIONSSITAPRED 50/1000 is indicated for:
Blood sugar management in adults with type 2 diabetes when diet and exercise are insufficient(Harrison's Principles of Internal Medicine, 20th Edition)
PRECAUTIONSPatients with a history of kidney or liver disease, heart failure, or lactic acidosis should use SITAPRED 50/1000 cautiously. Avoid excessive alcohol consumption, as it may increase the risk of lactic acidosis associated with Metformin. Pregnant or breastfeeding women should consult their healthcare provider before using this medication. Regular monitoring of blood glucose and kidney function is advised. This medication is not intended for individuals with type 1 diabetes or those experiencing diabetic ketoacidosis.PLEASE NOTEAlways consult your doctor before taking SITAPRED 50/1000 or any diabetes medication. Only a healthcare provider can determine if this medication is suitable for you based on your medical history and individual health needs. This information is for educational purposes and should not substitute professional medical advice. Do not self-prescribe diabetes medications without consulting a healthcare provider.